Heart failure-induced atrial remodelling promotes electrical and conduction alternans
نویسندگان
چکیده
منابع مشابه
Atrial remodelling in heart failure: recent developments and relevance for heart failure with preserved ejection fraction
As specialized compartments of the heart, the atria feature unique mechanical and structural properties that differ considerably from those of the ventricular myocardium. Beyond their contribution to cardiac output as a reservoir, conduit, and booster pump at different phases of the cardiac cycle, the atria determine heart rhythm, regularity, and rate (chronotropy). They also function as mechan...
متن کاملAblation of atrial fibrillation in patients with heart failure: reversal of atrial and ventricular remodelling.
INTRODUCTION The management of patients with heart failure and atrial fibrillation (AF) is a medical challenge, especially in the case of patients in whom sinus rhythm or rate control cannot be achieved with optimal pharmaceutical treatment. METHODS Thirteen consecutive patients (11 men and 2 women, 35-70 years old, median age 55 +/- 23 years) with heart failure (NYHA I-IV, median ejection fr...
متن کاملElectrical alternans vs. pseudoelectrical alternans
Beat-to-beat variations in QRS amplitude or axis may be caused by several conditions.
متن کاملEnergy metabolism in heart failure and remodelling.
Myocytes of the failing heart undergo impressive metabolic remodelling. The time line for changes in the pathways for ATP synthesis in compensated hypertrophy is: flux through the creatine kinase (CK) reaction falls as both creatine concentration ([Cr]) and CK activity fall; increases in [ADP] and [AMP] lead to increases in glucose uptake and utilization; fatty acid oxidation either remains the...
متن کاملEnhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure.
AIMS Cardiac hypertrophy and heart failure are associated with QT prolongation and lethal ventricular arrhythmias resulting from decreased K(+) current densities and impaired repolarization. Recent studies in mouse models of physiological cardiac hypertrophy revealed that increased phosphoinositide-3-kinase-α (PI3Kα) signalling results in the up-regulation of K(+) channels and the normalization...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2020
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1008048